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Phrases R: R40: Effet cancrogne suspect. Risque possible deffets irrversibles. R61: Risque pendant la grossesse deffets nfastes pour lenfant.
Phrases S: S45: En cas daccident ou de malaise, consulter immdiatement un mdecin (si possible, lui montrer ltiquette). S53: viter lexposition - se procurer des instructions spciales avant lutilisation. S36/37/39: Porter un vtement de protection appropri, des gants et un appareil de protection des yeux/du visage.
H350: Peut provoquer le cancer (indiquer la voie d'exposition s'il est formellement prouv qu'aucune autre voie d'exposition ne conduit au mme danger) H361: Susceptible de nuire la fertilit ou au ftus (indiquer l'effet s'il est connu)(indiquer la voie d'exposition s'il est formellement prouv qu'aucune autre voie d'exposition ne conduit au mme danger) P201: Se procurer les instructions avant utilisation. P281: Utiliser lquipement de protection individuel requis. P308: EN CAS dexposition prouve ou suspecte: P313: Consulter un mdecin.
La testostrone est une hormone strodienne, du groupe des andrognes. Chez les mammifres la testostrone est scrte essentiellement par les testicules des mles (et en plus faibles quantits par les glandes surrnales et quelques autres tissus). C'est la principale hormone sexuelle mle et le strode anabolisant originel.
Chez l'homme, la testostrone joue un rle cl dans la sant et le bien-tre, en particulier dans le fonctionnement sexuel. Entre autres exemples ces effets peuvent tre une libido plus importante, une nergie accrue, une augmentation de la production de cellules sanguines et une protection contre l'ostoporose. En moyenne, un homme adulte produit environ 40 60 fois plus de testostrone qu'une femme adulte, mais les femmes sont d'un point de vue comportemental (plus que d'un point de vue anatomique ou biologique), plus sensibles l'hormone[4][rf.insuffisante]. Cependant l'chelle d'une population, les gammes de concentration pour les hommes et les femmes sont trs tendues, de telle sorte qu'elles se chevauchent respectivement pour les valeurs basses et hautes.
Cette hormone est galement produite chez la femme (par les ovaires) en plus faible quantit et est responsable, chez elle aussi, du dsir sexuel.
Suite la diffrenciation du gonade en testicule (diffrenciation induite par la protine TDF code par le gne SRY mais dont la formation est active par l'antigne H-Y), la testostrone intervient au niveau embryonnaire pour induire une masculinisation des organes gnitaux. Elle est scrte par les cellules de Leydig et a une action permanente et indispensable sur les vsicules sminales et la prostate.
Vers la 12e semaine de grossesse, la rgression des canaux de Mller est provoque par la scrtion d'HRM (Hormone de rgression mllrienne). En mme temps, la testostrone qui sera scrte quant elle va favoriser le dveloppement des canaux de Wolff en pididyme. Dans le canal diffrenci se forment des vsicules sminales et la prostate. Ce sont ces hormones testiculaires qui sont responsables de la diffrenciation masculine.
Lors de la phase embryonnaire, la testostrone, avec l'hormone de rgression mllrienne (HRM), participe la mise en place des caractres sexuels:
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