OMICS Group-Journal of Steroids Hormonal Science-2157-7536
The regulatory mechanisms of physical activity are postulated to include environmental and biological/genetic factors. In particular,the sex steroids appear to have profound effects on wheel running in rodents. The purpose of this project was to investigate the effects of 17 beta;-estradiol and testosterone on wheel running distance, duration, and speed in male and female C57BL/6J mice. The mice (N=46) were provided free access to running wheels interfaced with computers to track daily running distance, duration, and speed. Activity was assessed at baseline in intact mice, after surgical gonadectomy, and after replacement with either 17 beta;- estradiol or testosterone. Upon removal of the gonads, physical activity levels were significantly reduced in both males and females.
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