Category Archives: HYPOGONADISM

Reading Time: < 1 minuteRepros Therapeutics Inc. ( RPRX ) is expected to report third-quarter 2014 results on Nov 6. Let's see how things are shaping up for this announcement. Factors at Play Last quarter, the company had posted a negative earnings surprise of 2.7%. Being a clinical-stage biotech company, Repros will continue to face an increase in R&D expenditure. Since the company does not generate any product revenues yet, investor focus will remain on its pipeline, particularly the status of the new drug application for Androxal, which is slated for submission by year-end. Androxal is the company's most advanced candidate and is being … Read more »

Reading Time: 4 minutesThe hormone testosterone is responsible for numerous sex characteristics in men including the growth and development of the sex and reproductive organs. In addition to assisting with fat distribution, bone mass and deepening of the voice, testosterone also helps keep up energy levels, sex drive and fertility. As men age, their production of testosterone naturally begins to decline. However, some men may develop a testosterone deficiency during their life. This disorder is known as hypogonadism. What Is It? Hypogonadism is one of the main causes of male infertility. It is estimated that 13 million men in the United States alone … Read more »

Reading Time: 2 minutesHypogonadism is a medical term for a defect of the reproductive system which results in lack of function of the gonads (ovaries or testes). Hypogonadism may occur if the hypothalamic-pituitary-gonadal axis is interrupted at any level. Hypergonadotropic hypogonadism (primary hypogonadism) results if the gonad does not produce the amount of steroid sufficient to suppress secretion of LH and FSH at normal levels. Hypogonadism resulting from defects of the gonads is traditionally referred to as primary hypogonadism. Examples include Klinefelter syndrome and Turner syndrome. Hypogonadism resulting from hypothalamic or pituitary defects are termed secondary hypogonadism or central hypogonadism (referring to the … Read more »

Reading Time: 2 minutesEarly symptoms of low testosterone in men include low libido (sex drive). As levels become very low, sexual dysfunction (also called "erectile dysfunction (ED)" or "impotence") often develops. Other signs and symptoms of low testosterone may include depression, fatigue, osteoporosis, loss of muscle mass, an increase in abdominal fat, development of breast tissue (gynecomastia) and infertility. Symptoms of low testosterone in women may include low libido (sex drive), sexual dysfunction, fatigue, loss of muscle mass, an increase in body fat and bone loss. Pituitary Symptoms There are many causes of low testosterone. These can be differentiated with hormone testing. Pituitary … Read more »

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Reading Time: 2 minutesRepros Therapeutics Inc. ( RPRX ) announced positive top-line data on its secondary hypogonadism candidate, Androxal, from a pivotal phase III study. Repros had initiated two identical, 17-week, double-blind ZA-304 and ZA-305 studies to compare the safety and efficacy of Androxal with a testosterone replacement therapy (topical gel) and placebo in restoring and maintaining testicular function. ZA-305 Study Data The ZA-305 study was the first of the two identical pivotal studies. In the study, Androxal demonstrated superiority on several assessments including the two co-primary endpoints and several secondary endpoints. In patients receiving Androxal, percent change in sperm concentration from baseline … Read more »

Reading Time: < 1 minuteExperts are calling for a full evaluation of the risks and benefits of hormone therapy for older men with declining levels of testosterone. The statement by the Endocrine Society was prompted by recent studies, one from the Veterans Health Care System and the other from the National Institutes of Health, that have raised concerns about the risks of testosterone therapy for older men with a history of heart disease. Testosterone is already approved for the treatment of hypogonadism, or low hormone production, because it is linked to diseases of the testes, pituitary and hypothalamus. But it has not been approved … Read more »

Reading Time: 2 minutesRepros Therapeutics Inc. ( RPRX ) reported second quarter 2014 loss of 38 cents per share, in line with the year-ago loss but a penny wider than the Zacks Consensus Estimate of a loss of 37 cents. Repros Therapeutics - Earnings Surprise | FindTheBest The company's revenues for the second quarter of 2014 were $2,000 as compared to $1,000 in the year-ago period, reflecting higher interest income as a result of a higher cash balance. Quarter in Details Both general and administrative (G&A) expenses and research and development (R&D) expenses were up during the reported quarter. While G&A expenses increased … Read more »

Reading Time: 8 minutesOverview Male hypogonadism is a condition in which the body doesn't produce enough of the hormone that plays a key role in masculine growth and development during puberty (testosterone) or enough sperm or both. You can be born with male hypogonadism, or it can develop later in life, often from injury or infection. The effects — and what you can do about them — depend on the cause and at what point in your life male hypogonadism occurs. Some types of male hypogonadism can be treated with testosterone replacement therapy Symptoms Hypogonadism can begin during fetal development, before puberty or … Read more »

Reading Time: 4 minutesDefinition Hypogonadism occurs when the body's sex glands produce little or no hormones. In men, these glands (gonads) are the testes. In women, these glands are the ovaries. Gonadal deficiency The cause of hypogonadism can be primary or central. In primary hypogonadism, the ovaries or testes themselves do not function properly. Causes of primary hypogonadism include: The most common genetic disorders that cause primary hypogonadism are Turner syndrome (in women) and Klinefelter syndrome (in men). If you already have other autoimmune disorders you may be at higher risk of autoimmune damage to the gonads. These can include disorders that affect … Read more »

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Reading Time: < 1 minuteWhat is Hypogonadism? Hypogonadism occurs when your sex glands produce little or no sex hormones. The sex glands, also called gonads, are the testes in men and the ovaries in women. Sex hormones help control sex characteristics, such as breast and testicle development, and pubic hair growth. Sex hormones also play a role in menstrual cycles and sperm production. Hypogonadism may also be called gonad deficiency. In males, it may be called low serum testosterone or andropause. Most cases of this disorder can be successfully treated. 9 Warning Signs of Low Testosterone There are two types of hypogonadism: primary and … Read more »

Reading Time: 2 minutesHypogonadism? I have been checked and found out to be low in progesterone. I have taken profasi and pregnyl injections last month still no luck. Been trying to get pregnant for two years now,was on clomid from nov 2005-oct 2006,stopped when taking injections. When should i go for check up to check if the injections increased my progesterone level? Thanks for your anticipated assistance. ---------- ---------- For women who have not had their uterus removed, combination treatment with estrogen and progesterone is often recommended to decrease the chances of developing endometrial cancer. In addition, low dose testosterone can be added … Read more »

Reading Time: < 1 minuteHypogonadotropic hypogonadism (HH), also known as secondary or central hypogonadism, as well as gonadotropin-releasing hormone deficiency or gonadotropin deficiency (GD), is a condition which is characterized by hypogonadism due to an impaired secretion of gonadotropins, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH), by the pituitary gland in the brain, and in turn decreased gonadotropin levels and a resultant lack of sex steroid production.[1] The type of HH, based on its cause, may be classified as either primary or secondary. Primary HH, also called isolated HH, is responsible for only a small subset of cases of HH, and is characterized … Read more »

Reading Time: < 1 minuteLondon, Oct 19 (ANI): Obese teenage boys have up to 50 percent less testosterone than their leaner pals - increasing their risk of infertility later in life, a study led by an Indian-origin researcher has warned. Researchers said that the results were a "grim message" for overweight young adults. The study by scientists at the University at Buffalo in the US, shows for the first time that obese young men aged 14 to 20 have around half the total testosterone than normal weight youths, the Daily Mail reported. The same research team first reported in 2004 that the presence of … Read more »

Reading Time: 2 minutesScienceDaily (Oct. 9, 2012) An SGH study has revealed that considering all osteoporotic patients as having simple osteoporosis and treating all of them alike by putting them on potent long term medication without finding out the cause of their osteoporosis may be ineffective and in most cases downright harmful. Secondary osteoporosis is a rather common but lesser known type of osteoporosis that affects men and women of any age. It is caused by certain medical conditions that result in bone loss or interfere with development of peak bone mass. Contributors of secondary osteoporosis include conditions such as hypercalciuria, hyperthyroidism, hyperparathyroidism, … Read more »

Reading Time: < 1 minuteCauses, signs and symptoms of hypogonadism Hypogonadism is a reduction or absence of hormone secretions from the sex glands (gonads). In men the hormones are secreted from the testes; in women the hormones come from the ovaries. Many types of hypogonadism can be treated and the condition does have a good prognosis. There are two types of hypogonadism; Primary, where the testes fail to function properly, and Central hypogonadism where the centers of the brain responsible for control of the gonads (the hypothalamus and pituitary) do not function properly. Causes of primary and central hypogonadism Primary hypogonadism occurs for a … Read more »

Reading Time: 2 minutesTORONTO, ONTARIO--(Marketwire - Oct 22, 2012) - Trimel Pharmaceuticals Corporation (TRL.TO) ("the "Company" or "Trimel") today announced positive results from a recently completed independent market research study on the reception by physicians of CompleoTRT, Trimel''s innovative ''no-touch'' treatment for male hypogonadism, or more commonly referred to as "Low T".According to IMS Health, 2011 sales of marketed treatments for Low T were approximately $1.6 billion, and have been projected to reach $5 billion by 2017, according to a leading syndicated market research company. The quantitative study conducted in the United States surveyed 113 physicians covering urologists, endocrinologists and primary care physicians … Read more »

Reading Time: 2 minutesMale hypogonadismis defined as the underproduction of sperm or testosterone, or both, by the testes (also called testicles). Starting at puberty, the pituitary gland releases luteinizing hormone (LH), which stimulates the testicles to produce testosterone, the hormone responsible for male physical characteristics. In the testicles, follicle stimulating hormone (FSH) and LH also act together to stimulate the production of sperm. Diagnosis of male hypogonadism begins with a medical history and physical examination. Many possible symptoms and signs may suggest low testosterone, orandrogen deficiency, in adult men: Blood tests determine whether testosterone levels are in the normal range. This is generally … Read more »

Reading Time: < 1 minuteYour doctor will conduct a physical exam during which he or she will note whether your sexual development, such as your pubic hair, muscle mass and size of your testes, is consistent with your age. Your doctor may test your blood level of testosterone if you have any of the signs or symptoms of hypogonadism. Early detection in boys can help prevent problems from delayed puberty. Early diagnosis and treatment in men offer better protection against osteoporosis and other related conditions. Doctors base a diagnosis of hypogonadism on symptoms and results of blood tests that measure testosterone levels. Because testosterone … Read more »